Efficient Synthesis of α-Chloroketones Catalyzed by Fluorous Hydrazine-1,2-Bis(Carbothioate) Organocatalyst

Hydrazine (antidepressant) Organometallic Chemistry Reaction conditions
DOI: 10.1007/s10562-015-1676-3 Publication Date: 2015-12-31T06:30:41Z
ABSTRACT
A novel and recoverable fluorous hydrazine-carbothioate organocatalyst was prepared. It could catalyze α-chlorination of alkyl ketones with N-chlorosuccinimide as chlorine source under mild reaction conditions. The reaction afforded the corresponding α-chlorinated carbonyl compounds with excellent yields at rapid reaction speed.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (30)
CITATIONS (8)