Efficient Synthesis of α-Chloroketones Catalyzed by Fluorous Hydrazine-1,2-Bis(Carbothioate) Organocatalyst
Hydrazine (antidepressant)
Organometallic Chemistry
Reaction conditions
DOI:
10.1007/s10562-015-1676-3
Publication Date:
2015-12-31T06:30:41Z
AUTHORS (2)
ABSTRACT
A novel and recoverable fluorous hydrazine-carbothioate organocatalyst was prepared. It could catalyze α-chlorination of alkyl ketones with N-chlorosuccinimide as chlorine source under mild reaction conditions. The reaction afforded the corresponding α-chlorinated carbonyl compounds with excellent yields at rapid reaction speed.
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