Extensive diagnostic work-up for patients with carcinoma of unknown primary
Adult
Aged, 80 and over
Male
Adolescent
EMC OR-01
Infant, Newborn
Radboud University Medical Center
Infant
Middle Aged
Radboudumc 14: Tumours of the digestive tract RIHS: Radboud Institute for Health Sciences
3. Good health
Young Adult
03 medical and health sciences
0302 clinical medicine
SDG 3 - Good Health and Well-being
Child, Preschool
Humans
Neoplasms, Unknown Primary
Female
Child
Aged
DOI:
10.1007/s10585-021-10073-3
Publication Date:
2021-01-30T05:02:35Z
AUTHORS (7)
ABSTRACT
Patients with carcinoma of unknown primary (CUP) present with metastatic disease without an identified primary tumour. The unknown site of origin makes the diagnostic work-up and treatment challenging. Since little information is available regarding diagnostic work-up and treatment in daily practice, we collected and analysed these in a patient cohort with regard to the recommendations of the national CUP guideline. Data of 161 patients diagnosed with CUP in 2014 or 2015 were extracted from the Netherlands Cancer Registry (NCR) and supplemented with diagnostic work-up information from patient files and analysed. Patients underwent an average of five imaging studies during the diagnostic phase (range 1-17). From the tests as recommended in the national guideline on CUP, a chest X-ray was most commonly performed (73%), whereas a PET-CT was done in one out of four patients (24%). Biopsies were taken in 86% of the study population, with Cytokeratin 7 being the most frequently tested histopathological marker (73%). Less than half of patients received therapy (42%). CUP patients undergo extensive diagnostic work-up. The performance status did not influence the extent of the diagnostic work-up in CUP patients, but it was an important factor for receiving treatment.
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