Cyclization products of N-fluorophenyl-β-alanines and their properties

• DOI: 10.1007/s10593-006-0157-4
• Publication Date: 2006-09-20T04:15:55Z
• Authors: R. Vaickelioniene; V. Mickevicius
• Keywords: Hydrazine (antidepressant); Itaconic acid; Benzimidazole; Pyrazole

Interaction of 2-and 4-fluorophenylamines with acrylic and itaconic acids leads to the synthesis of the corresponding N-substituted β-alanines, the cyclization of which leads to derivatives of dihydropyrimidinone, 4-carboxy-2-pyrrolidinone, and tetrahydropyridone. Compounds having benzimidazole, pyrazole, and hydrazine fragments in the molecule have been obtained from 4-carboxy-1-(4-fluorophenyl)-2-pyrrolidinone.