Stereochemistry of the aza-Michael reaction with natural alantolactones

• DOI: 10.1007/s10593-012-1047-6
• Publication Date: 2012-08-30T17:28:25Z
• Authors: S. G. Klochkov; I. V. Anan’ev; S. A. Pukhov; S. V. Afanas’eva
• Keywords: Furan

Hydrogenated 3-aminomethylnaphtho[2,3-b]furan-2-ones were synthesized by the reaction of natural alantolactones with pharmacophoric amines. Determination of the newly formed asymmetric center configuration by two-dimensional NMR data is presented. The structure of the obtained compounds was proved by X-ray structural analysis.