Interaction of condensed tetrahydropyrido[4,3-d]pyrimidin-4-ones with dehydrobenzene – synthesis of 6-vinylpyrimidinones fused with five-membered heterocycle containing two or three heteroatoms

• DOI: 10.1007/s10593-018-2250-x
• Publication Date: 2018-03-26T00:11:16Z
• Authors: Aleksey V. Varlamov; Natalia I. Guranova; Tatiana N. Borisova; Elena A. Sorokina; Alexander V. Aksenov; Leonid G. Voskres...
• Keywords: arynes; Hofmann cleavage; pyridopyrimidinones; azole ring; 540; annulation; 01 natural sciences; dehydrobenzene; vinyl-substituted pyrimidinones; 0104 chemical sciences

[Figure not available: see fulltext.] The reaction between dehydrobenzene and tetrahydropyrido[4,3-d]pyrimidin-4-ones condensed with isoxazole, thiazole, thiadiazole, or triazole rings resulted in Hofmann cleavage of the tetrahydropyridine moiety with the formation of 6-vinyl-substituted pyrimidones fused with the corresponding azole rings. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.