Structural characteristics and antitumor activity of a new chrysolaminaran from the diatom alga Synedra acus

• DOI: 10.1007/s10600-010-9510-z
• Publication Date: 2010-03-24T08:01:47Z
• Authors: M. I. Kusaikin; S. P. Ermakova; N. M. Shevchenko; V. V. Isakov; A. G. Gorshkov; A. L. Vereshchagin; M. A. Grachev; T. N. Zvyagintseva
• Keywords: 0303 health sciences; 03 medical and health sciences

The 1→3;1→6-β-D-glucan chrysolaminaran with molecular weight 8.5 kDa and 3.6:1 ratio of 1→3:1→6 bonds was isolated from cultivated diatom alga Synedra acus and characterized. It was shown that the isolated chrysolaminaran inhibited growth and colony formation of human colon tumor cells.