Bimolecular Compounds Based on Natural Metabolites
Parthenolide
Sesquiterpene lactone
DOI:
10.1007/s10600-018-2380-5
Publication Date:
2018-06-06T05:58:31Z
AUTHORS (4)
ABSTRACT
New alkaloid-containing derivatives of the sesquiterpene lactones arglabin, grosshemin, 3,4β-epoxyarglabin, argolide, and parthenolide were prepared for the first time. Their structures were studied using PMR, 13C NMR, and mass spectra and an X-ray crystal structure analysis. Chemo- and regioselective reactions of the sesquiterpene lactones and alkaloids were observed. The synthesized compounds exhibited anthelmintic and hepatoprotective activity and cytotoxicity.
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