Bimolecular Compounds Based on Natural Metabolites

• DOI: 10.1007/s10600-018-2380-5
• Publication Date: 2018-06-06T05:58:31Z
• Authors: S. M. Adekenov; A. S. Kishkentaeva; Zh. R. Shaimerdenova; G. A. Atazhanova
• Keywords: Parthenolide; Sesquiterpene lactone

New alkaloid-containing derivatives of the sesquiterpene lactones arglabin, grosshemin, 3,4β-epoxyarglabin, argolide, and parthenolide were prepared for the first time. Their structures were studied using PMR, 13C NMR, and mass spectra and an X-ray crystal structure analysis. Chemo- and regioselective reactions of the sesquiterpene lactones and alkaloids were observed. The synthesized compounds exhibited anthelmintic and hepatoprotective activity and cytotoxicity.