Association of Adenosine Deaminase, Superoxide Dismutase, and Catalase Activities with Helicobacter pylori

• DOI: 10.1007/s10620-005-3050-6
• Publication Date: 2006-01-13T09:39:23Z
• Authors: E. Bulbuloglu; F. Inanc; S. Bakaris; B. Kantarceken; A Cetinkaya; R. Çağlar; T. Kale Ilhami; M. Kilinc
• Keywords: Adult; Male; Adolescent; Helicobacter pylori; Adenosine Deaminase; Biopsy, Needle; Middle Aged; Catalase; Immunohistochemistry; Helicobacter Infections; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Case-Control Studies; Gastritis; Gastroscopy; Disease Progression; Humans; Female; Biomarkers; Aged; Follow-Up Studies; Probability

Our purpose was to investigate associations between adenosine deaminase (ADA), superoxide dismutase (SOD), and catalase (CAT) activities and H. pylori.Ninety-nine patients were studied. Eight antral mucosal biopsies were taken for biochemical assessment of ADA, CAT, AND SOD activity and histological assessment. H. pylori density wAS evaluated according to the updated Sydney system. Patients were divided into three groups according to Sydney classification. ADA activity was found to be higher in patients having H. pylori in the present study. Also, ADA activity was higher in patients with a severe density of H. pylori. SOD level was found to be significantly higher with increased H. pylori density in our study (P < 0.05). In addition, SOD activity was higher in it H. Pylori-positive than H. pylori-negative patients. We did not find CAT activity in some antral tissue specimens. The significantly high levels of ADA activity in patients with H. pylori infection may reflect the regulator role of ADA in acid secretion. The higher ADA level with increased H. pylori density and H. pylori positivity indicate the probable malign lymphoid process of the stomach. But these findings must be confirmed with larger studies that include different gastric lesions.