Serum Zinc and Selenium in Children with Inflammatory Bowel Disease: A Multicenter Study in Japan
Adult
0301 basic medicine
Adolescent
Malnutrition
Inflammatory Bowel Diseases
3. Good health
Selenium
Zinc
03 medical and health sciences
Crohn Disease
Japan
Chronic Disease
Humans
Colitis, Ulcerative
Child
Retrospective Studies
DOI:
10.1007/s10620-021-07078-z
Publication Date:
2021-06-08T09:06:29Z
AUTHORS (19)
ABSTRACT
Reports of zinc and selenium deficiencies accompanying inflammatory bowel disease (IBD) mostly have originated from Western countries and concerned adult patients. Whether Japanese children with IBD have similar deficiencies remained unclear.We aimed to elucidate differences in serum zinc and selenium concentrations in Japanese children between types of IBD.Children under 17 years old undergoing care at 12 Japanese pediatric centers were retrospectively enrolled between November 2016 and February 2018 to 3 groups representing Crohn's disease (CD), ulcerative colitis (UC), and normal controls (NC) with irritable bowel syndrome or no illnesses. Serum zinc and selenium were measured by atomic absorption spectrophotometry. Zinc and selenium deficiencies were defined by serum concentrations < 70 μg/dL and < 9.5 μg/dL, respectively.Subjects included 98 patients with CD (median age, 13 years), 118 with UC (11 years), and 43 NC (11 years). Serum zinc and selenium were significantly lower in CD (median, 64 and 12.6 μg/dL respectively) than in UC (69 and 14.6; P < 0.05 and P < 0.001) or NC (77 and 15.7; P < 0.01 and P < 0.001). Zinc deficiency was significantly more prevalent in CD (60.2%) than in NC (37.2%; P < 0.05), but not than in UC (51.7%; P = 0.22). Selenium deficiency was significantly more prevalent in CD (15.3%) than in UC (5.9%; P < 0.05) or NC (0%; P < 0.01).In Japanese children under 17 years old, serum zinc and selenium were significantly lower in CD than in UC or NC. Zinc and selenium should be monitored, and supplemented when deficient, in children with IBD, especially CD.
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