Photopic negative response of full-field electroretinography in patients with different stages of glaucomatous optic neuropathy

• DOI: 10.1007/s10633-016-9528-z
• Publication Date: 2016-01-29T14:54:11Z
• Authors: Marta Kirkiewicz; Wojciech Lubiński; Krzysztof Penkala
• Keywords: Electroretinography; Optic nerve diseases

To evaluate photopic negative response (PhNR) discrimination ability between healthy and glaucomatous patients.Ninety eyes of 50 patients with primary open angle glaucoma (POAG) 45 23 age- sex-matched controls were investigated. Based on European Glaucoma Society criteria, POAG divided into three groups: early, moderate advanced glaucoma. Following measurements analysed: mean defect (MD) from Humphrey Visual Field Analyzer, SITA standard 24-2 white perimetry; nerve fibre index (NFI) obtained scanning laser polarimetry; GDx PhNR amplitude PhNR/b-wave ratio. was elicited by red stimuli flash strength 1.6 cd s/m(2) blue background 25 cd/m(2). Correlations retinal ganglion cells function (PhNR), sensitivity structure calculated. Sensitivity specificity parameters calculated formulas. Receiver operating characteristic (ROC) curves used to determine optimal cut-off values. The area under the curve (AUC) compare ROC results ratio.PhNR ratio significantly reduced in groups compared controls. detect early equal 53.3 90.0% for 60.0 70.0% ratio; 63.3 80.0% 86.7% 76.6 amplitude, 90.0 73.3% There no significant differences AUC (0.76-0.86) (0.78-0.86), p > 0.05. amplitudes ratios correlated MD measured SAP NFI (p < 0.05). decreases advancement visual field defects patients.PhNR reveals dysfunction RGCs stage POAG. has good detecting patients. might be a useful test diagnosis.