Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam Study

• DOI: 10.1007/s10654-016-0132-z
• Publication Date: 2016-03-05T04:34:30Z
• Authors: Natalie Terzikhan; Katia M. C. Verhamme; Albert Hofman; Bruno H. Stricker; Guy G. Brusselle; Lies Lahousse
• Keywords: Rotterdam Study; Rate ratio

COPD is the third leading cause of death in world and its global burden predicted to increase further. Even though prevalence well studied, only few studies examined incidence a prospective standardized manner. In population-based cohort study (Rotterdam Study) enrolling subjects aged ≥45, was diagnosed based on pre-bronchodilator obstructive spirometry (FEV1/FVC < 0.70). absence an interpretable within Rotterdam Study, cases were defined as having by physician basis clinical presentation lung function measured general practitioner or respiratory physician. Incidence rates calculated dividing number incident total person years at risk. this 14,619 participants, 1993 with identified whom 689 prevalent ones 1304 ones. The overall rate (IR) 8.9/1000 person-years (PY); 95 % Confidence Interval (CI) 8.4-9.4. IR higher males smokers. proportion female participants without history smoking 27.2 %, while 7.3 males. Study 4.7 approximately 9/1000 PY, never-smokers among substantial.