The LifeCycle Project-EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents
Life course approach
DOI:
10.1007/s10654-020-00662-z
Publication Date:
2020-07-23T09:03:53Z
AUTHORS (160)
ABSTRACT
Early life is an important window of opportunity to improve health across the full lifecycle. An accumulating body evidence suggests that exposure adverse stressors during early leads developmental adaptations, which subsequently affect disease risk in later life. Also, geographical, socio-economic, and ethnic differences are related inequalities from onwards. To address these public challenges, many European pregnancy childhood cohorts have been established over last 30 years. The enormous wealth data has led new biological insights impact for their could be further increased by combining different cohorts. Combining will lead possibility identifying smaller effect estimates, better identify groups factors leading lifecycle countries. it enables research on causal understanding modelling course trajectories. EU Child Cohort Network, Horizon2020-funded LifeCycle Project, brings together nineteen cohorts, including more than 250,000 children parents. A large set variables harmonised standardized harmonized kept within each institution can accessed external researchers through a shared federated analysis platform using R-based DataSHIELD, takes relevant national international regulations into account. Network open character. All protocols harmonization setting up available online. creates great opportunities use beyond Project duration. It also provides novel model collaborative infrastructures with individual-level data. translate results recommendations targeted prevention strategies trajectories current future generations optimizing earliest phases
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (93)
CITATIONS (118)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....