Effect of Hochuekkito on Alveolar Macrophage Inflammatory Responses in Hyperglycemic Mice

• DOI: 10.1007/s10753-012-9441-x
• Publication Date: 2012-02-25T01:50:47Z
• Authors: Masayuki Nakayama; Yukihiko Sugiyama; Hideaki Yamasawa; Manabu Soda; Naoko Mato; Tatsuya Hosono; Masashi Bando
• Keywords: TLR5; Alveolar macrophage

Diabetes mellitus reduces immunological activity and increases susceptibility to various infections. Hochuekkito (TJ-41) has been reported improve the weakened physical condition of chronic diseases. BALB/c mice were divided into three groups; groups A B fed a standard diet, group C, TJ-41 diet. Two weeks after starting these diets, hyperglycemia was induced in C by injection with streptozotocin. later, bronchoalveolar lavage performed. Toll-like receptor (TLR) ligands (TLR2: peptidoglycan, PGN; TLR4: lipopolysaccharide, LPS; TLR5: flagellin, FLG) used stimulate alveolar macrophages (AMs), TNF-α production measured. Under hyperglycemic conditions PGN or FLG stimulation, from AMs significantly reduced compared A. However, treatment (group C) improved impaired TNF-α. These results suggest that, under conditions, can inflammatory responses stimulation TLR ligands.