Assessment of Inflammatory and Oxidative Biomarkers in Obesity and Their Associations with Body Mass Index

• DOI: 10.1007/s10753-012-9538-2
• Publication Date: 2012-09-08T09:35:19Z
• Authors: Sílvia Juliane Piva; Etiane Tatsch; José Antonio Main...; Guilherme Vargas ...; Helena Kober; Thiago Duarte; Marta Maria Medei...; Ivana Beatrice Mâ...; Maria Beatriz Mor...; Rafael Noal Moresco
• Keywords: Blood Glucose; Inflammation; Male; 2. Zero hunger; Interleukin-6; Cholesterol, HDL; Cholesterol, LDL; Middle Aged; Nitric Oxide; Body Mass Index; 3. Good health; Oxidative Stress; 03 medical and health sciences; Apolipoproteins; 0302 clinical medicine; Creatinine; Albuminuria; Humans; Female; Obesity; Biomarkers; Serum Albumin; Triglycerides; Glomerular Filtration Rate

The aim of this study was to evaluate the inflammatory and oxidative biomarkers' levels in obese subjects and their associations with body mass index (BMI), in order to investigate the role of these biomarkers in obesity. Fasting glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, apolipoprotein A, apolipoprotein B, albumin, urinary albumin, creatinine, glomerular filtration rate, interleukin-6 (IL-6), nitrate/nitrite (NOx), and ischemia-modified albumin (IMA) were measured in 93 subjects divided according to different BMI. IL-6, urinary albumin, and IMA levels were significantly higher in obese subjects. However, the levels of NOx were significantly lower in this population. Significant correlations between BMI and IL-6 (r = 0.326, P = 0.002), NOx (r = -0.249, P = 0.021), urinary albumin (r = 0.270, P = 0.008), and IMA (r = 0.286, P = 0.005) were reported. We have shown an increase of IL-6, urinary albumin, and IMA combined with lower levels of NOx in obese patients and an association between of these biomarkers with BMI, suggesting a possible interplay of oxidative stress, inflammation, and endothelial dysfunction state in obesity.