Evaluation of antiulcer and antisecretory potential of Linum usitatissimum fixed oil and possible mechanism of action
Atropine
0301 basic medicine
0303 health sciences
Linseed Oil
Aspirin
Ethanol
Guinea Pigs
Indomethacin
Hydrogen-Ion Concentration
Promethazine
Acetylcholine
Cholinergic Antagonists
3. Good health
03 medical and health sciences
Gastric Mucosa
Ileum
Flax
Histamine H1 Antagonists
Animals
Cimetidine
Ligation
Misoprostol
Histamine
Muscle Contraction
DOI:
10.1007/s10787-010-0037-5
Publication Date:
2010-04-19T19:13:33Z
AUTHORS (2)
ABSTRACT
The aim of the study was to evaluate the antiulcer activity of Linum usitatissimum fixed oil against aspirin-, indomethacin-, ethanol-, reserpine-, serotonin- and stress-induced gastric ulceration in rats and histamine-induced gastric ulceration in guinea pigs. Attempts were also made to evaluate the in vitro anticholinergic and antihistaminic activity and in vivo antisecretary and antiulcer activity of oil following pylorus ligation in rats. L. usitatissimum fixed oil exhibited significant antiulcer activity against different ulcerogens in experimental animal models. The fixed oil significantly inhibited acetylcholine- and histamine-induced contraction of guinea pig and rat ileums, respectively, suggesting its anticholinergic and antihistaminic activity. The oil also exhibited significant inhibitory effect on gastric secretion/total acidity and aspirin-induced gastric ulceration in pylorus-ligated rats. The lipoxygenase inhibitory, histamine antagonistic and antisecretory (anticholinergic) effects of the oil could probably have contributed towards antiulcer activity. L. usitatissimum fixed oil may be considered to be a drug of natural origin which possesses significant antiulcer activity. The present observation is the first experimental data showing antiulcer activity of L. usitatissimum fixed oil.
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