Comparison of intravitreal bevacizumab monotherapy and combined laser photocoagulation and intravitreal bevacizumab therapy in the same session in the treatment of aggressive retinopathy of prematurity

• DOI: 10.1007/s10792-024-03171-0
• Publication Date: 2024-07-02T14:03:38Z
• Authors: Şenol Sabancı; Mehmet Fatih Küçük; Elçin Süren; Muhammet Kazim Erol
• Keywords: Male; Vascular Endothelial Growth Factor A; Laser Coagulation; Infant, Newborn; Infant; Angiogenesis Inhibitors; Gestational Age; Combined Modality Therapy; Bevacizumab; Treatment Outcome; Intravitreal Injections; Humans; Retinopathy of Prematurity; Female; Retrospective Studies; Follow-Up Studies

To compare the results of intravitreal bevacizumab (IVB) monotherapy and combined intravitreal bevacizumab and laser photocoagulation (LPC) therapies applied in the same session to patients with aggressive retinopathy of prematurity (A-ROP) in our clinic.The study included 67 eyes of 37 patients diagnosed with A-ROP and treated. Forty-nine eyes treated with anti-vascular endothelial growth factor agent injection monotherapy for A-ROP treatment were included in the first group. The second group consisted of 18 eyes that received injection therapy and LPC treatment. The clinical findings of the two groups were investigated, and their treatment results were compared.Recurrence was observed in 19 of the 49 (38%) eyes in the first group, but there was no recurrence in any of the cases in the second group. While only IVB was applied to eight cases with recurrence, the combination of LPC and IVB treatment was applied to 11 cases. A second recurrence was detected in two of the eight cases that had received IVB monotherapy as a treatment for recurrence and in three of the 11 cases that had received LPC and IVB. The treatment outcomes of the two groups did not statistically significantly differ (P = 0.181).We consider that the combined simultaneous LPC and IVB treatment we applied in A-ROP cases is an effective approach, particularly for cases where there are concerns about the patient's ability to attend follow-up appointments.