Is There a ‘Regressive Phenotype’ of Autism Spectrum Disorder Associated with the Measles-Mumps-Rubella Vaccine? A CPEA Study

• DOI: 10.1007/s10803-005-0070-1
• Publication Date: 2006-04-27T16:54:37Z
• Authors: Jennifer Richler; Rhiannon Luyster; Susan Risi; Wan-Ling Hsu; Geraldine Dawson; Raphael Bernier; Michelle Dunn; Susan Hepburn; Susan L. Hyman; William M. McMahon; Julie Goudie-Nice; Nancy Minshew; Sally Rogers; Marian Sigman; M. Anne Spence; Wendy A. Goldberg; Helen Tager-Flusberg; Fred R. Volkmar; Catherine Lord
• Keywords: Male; Observer Variation; Parents; Communication; Regression, Psychology; 3. Good health; 03 medical and health sciences; Phenotype; 0302 clinical medicine; Surveys and Questionnaires; Humans; Female; Autistic Disorder; Child; Social Behavior; Measles-Mumps-Rubella Vaccine

A multi-site study of 351 children with Autism Spectrum Disorders (ASD) and 31 typically developing children used caregiver interviews to describe the children's early acquisition and loss of social-communication milestones. For the majority of children with ASD who had experienced a regression, pre-loss development was clearly atypical. Children who had lost skills also showed slightly poorer outcomes in verbal IQ and social reciprocity, a later mean age of onset of autistic symptoms, and more gastrointestinal symptoms than children with ASD and no regression. There was no evidence that onset of autistic symptoms or of regression was related to measles-mumps-rubella vaccination. The implications of these findings for the existence of a 'regressive phenotype' of ASD are discussed.