Polymorphisms of TCF7L2 and HHEX genes in Chinese women with polycystic ovary syndrome

• DOI: 10.1007/s10815-009-9377-8
• Publication Date: 2009-12-29T06:13:55Z
• Authors: Pei Xu; Yena Che; Yunxia Cao; XiaoKe Wu; Haixiang Sun; Fengjing Liang; Jing Sun; Lu Ke; Long Yi; Yong Wang
• Keywords: Adult; Homeodomain Proteins; 0301 basic medicine; Analysis of Variance; Genotype; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; 3. Good health; 03 medical and health sciences; Asian People; Haplotypes; Pituitary Hormones, Anterior; Humans; Female; Genetic Predisposition to Disease; TCF Transcription Factors; Transcription Factor 7-Like 2 Protein; Gonadal Hormones; Polycystic Ovary Syndrome; Transcription Factors

This study was to evaluate whether polymorphisms of TCF7L2 (rs7903146) and HHEX (rs1111875) genes responsible for insulin secretion are associated with the polycystic ovary syndrome (PCOS) in Chinese people.326 PCOS patients and 290 healthy individuals as controls were studied. Blood samples were obtained for DNA analyses and hormone measurements. Genotyping of the TCF7L2 (rs7903146) and HHEX (rs1111875) genes was carried out by the polymerase chain reaction-restriction fragment length polymorphism method.We did not find statistically significant differences in the distribution of the TCF7L2 rs7903146 and HHEX rs1111875 polymorphisms between the Chinese women with PCOS and the controls. Levels of hormones such as insulin, FSH, LH, LH/FSH, P, T and E2 were also similar between the different genotypes of the genes TCF7L2 and HHEX, respectively, which was confirmed within either the PCOS subjects or controls.There was no association of either of the two variants, rs7903146 of TCF7L2 and rs1111875 of HHEX, with the occurrence of PCOS in the Chinese population.