Reconstruction scheme for excitatory and inhibitory dynamics with quenched disorder: application to zebrafish imaging

• DOI: 10.1007/s10827-020-00774-1
• Publication Date: 2021-04-07T08:03:57Z
• Authors: Lorenzo Chicchi; Gloria Cecchini; Ihusan Adam; Giuseppe de Vito; Roberto Livi; Francesco Saverio...; Ludovico Silvestri; Lapo Turrini; Francesco Vanzi; Duccio Fanelli
• Keywords: Neurons; 0301 basic medicine; 0303 health sciences; disorder, zebrafish, light-sheet, two-photon; Models, Neurological; FOS: Physical sciences; Disordered Systems and Neural Networks (cond-mat.dis-nn); Condensed Matter - Disordered Systems and Neural Networks; Article; 03 medical and health sciences; Quantitative Biology - Neurons and Cognition; FOS: Biological sciences; Animals; Neurons and Cognition (q-bio.NC); Algorithms; Zebrafish

Abstract An inverse procedure is developed and tested to recover functional structural information from global signals of brains activity. The method assumes a leaky-integrate fire model with excitatory inhibitory neurons, coupled via directed network. Neurons are endowed heterogenous current value, which sets their associated dynamical regime. By making use mean-field approximation, the seeks reconstructing activity patterns distribution in-coming degrees, for both as well assigned currents. proposed scheme first validated against synthetic data. Then, time-lapse acquisitions zebrafish larva recorded two-photon light sheet microscope used an input reconstruction algorithm. A power law connectivity neurons found. Local degree distributions also computed by segmenting whole brain in sub-regions traced annotated atlas.