Preparation of cerium oxide–MWCNTs nanocomposite bulk modified carbon ceramic electrode: a sensitive sensor for tamoxifen determination in human serum samples

• DOI: 10.1007/s10854-021-06019-w
• Publication Date: 2021-05-03T18:02:50Z
• Authors: Sepideh Shafaei; Elyas Hosseinzadeh; Gulsah Saydan Kan...; Balal Khalilzadeh; Rahim Mohammad-Re...
• Keywords: Cerium oxide; Carbon fibers

Abstract In this study, cerium oxide and multi-walled carbon nanotubes nanocomposite was incorporated into the carbon ceramic electrode (CeO2-MWCNTs/CCE) as a renewable electrode for the electrocatalytic purposes. To demonstrate capability of the fabricated electrode, determination of Tamoxifen as an important anticancer drug with differential pulse voltammetry technique was evaluated. Linear range, limit of detection and sensitivity of the developed sensor were found to be 0.2-40 nM, 0.132 nM and 1.478 µA nM-1 cm-2, respectively. Ease of production, low cost and high electron transfer rate of CeO2-MWCNTs/CCE promise it as a novel electro-analytical tool for determination of important species in real samples.