In vitro fibroblast response to ultra fine grained titanium produced by a severe plastic deformation process
Titanium
0301 basic medicine
Biocompatible Materials
3T3 Cells
Prostheses and Implants
02 engineering and technology
Fibroblasts
Mice
03 medical and health sciences
Materials Testing
Animals
Stress, Mechanical
Particle Size
0210 nano-technology
Cell Proliferation
DOI:
10.1007/s10856-007-3204-5
Publication Date:
2007-07-16T23:00:13Z
AUTHORS (8)
ABSTRACT
The in vitro response of the mouse fibroblast cell line 3T3 on the surface of ultrafine grained titanium [produced by a severe plastic deformation (SPD) process] has been studied in this work. SPD Ti showed much higher strength than the coarse grained Ti and equivalent to that of Ti-6Al-4V alloy. Better cell proliferation was observed on SPD Ti compared to conventional Ti and Ti-6Al-4V alloy. This could be attributed to the increased surface free energy by reduction in the grain size and possibly the presence of a large number of nano size grooves at the triple point junctions in SPD Ti sample. There was no significant difference in the results of cytotoxicity tests of fine and coarse grained materials.
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