In vitro fibroblast response to ultra fine grained titanium produced by a severe plastic deformation process

Titanium 0301 basic medicine Biocompatible Materials 3T3 Cells Prostheses and Implants 02 engineering and technology Fibroblasts Mice 03 medical and health sciences Materials Testing Animals Stress, Mechanical Particle Size 0210 nano-technology Cell Proliferation
DOI: 10.1007/s10856-007-3204-5 Publication Date: 2007-07-16T23:00:13Z
ABSTRACT
The in vitro response of the mouse fibroblast cell line 3T3 on the surface of ultrafine grained titanium [produced by a severe plastic deformation (SPD) process] has been studied in this work. SPD Ti showed much higher strength than the coarse grained Ti and equivalent to that of Ti-6Al-4V alloy. Better cell proliferation was observed on SPD Ti compared to conventional Ti and Ti-6Al-4V alloy. This could be attributed to the increased surface free energy by reduction in the grain size and possibly the presence of a large number of nano size grooves at the triple point junctions in SPD Ti sample. There was no significant difference in the results of cytotoxicity tests of fine and coarse grained materials.
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