Preparation and characterization of ketoprofen-loaded microspheres for embolization
Ethanol
Polymers
Drug Compounding
T-Lymphocytes
Water
Complement System Proteins
04 agricultural and veterinary sciences
Embolization, Therapeutic
Models, Biological
Elasticity
Microspheres
Drug Delivery Systems
Freeze Drying
0404 agricultural biotechnology
Ketoprofen
Calibration
Wettability
Animals
Humans
0405 other agricultural sciences
DOI:
10.1007/s10856-011-4492-3
Publication Date:
2011-11-21T09:07:00Z
AUTHORS (5)
ABSTRACT
To deliver drug locally and relieve the syndrome of pain after uterine artery embolization, N-[tris (hydroxymethyl) methyl] acrylamide-gelatin microspheres were prepared based on inverse suspension polymerization and then separated into a number of subgroups (150-350, 350-560, 560-710, 710-1,000, and 1,000-1,430 μm) by wet-sieving. The microspheres were dried by lyophilization or by washing with anhydrous ethanol. And ketoprofen was loaded by soaking dried blank microspheres into concentrated ketoprofen ethanol solution. The ketoprofen loading level in different subgroups of microspheres was measured and found higher when the microspheres were dried by lyophilization. Equilibrium water content and mean diameters of microspheres decreased after drug loading, especially in subgroups with larger size. The microspheres went through the catheter without any difficulty. Compression and relaxation tests were performed on microspheres before lyophilization, embosphere™, microspheres after lyophilization and ketoprofen loading microspheres. The Young's moduli were 54.74, 64.19, 98.15, and 120.44 kPa, respectively. The release of ketoprofen from microspheres in different subgroups was studied by using the USPII method and T-cell apparatus, respectively. The results indicate that the release rate of ketoprofen depends upon the diameter of microspheres, the type of dissolution apparatus and the flow rate of media in the case that T-cell apparatus was applied. The CH50 test shows that the activation of complement by ketoprofen-loaded microspheres was lower than by blank ones.
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