Prediction of all-cause mortality from 24 month trajectories in patient-reported psychological, clinical and quality of life outcomes in uveal melanoma patients

• DOI: 10.1007/s10865-021-00252-8
• Publication Date: 2021-08-27T16:03:20Z
• Authors: Stephen L. Brown; Peter L. Fisher; Laura Hope-Stone; Heinrich Heimann; Rumana Hussain; M. Gemma Cherry
• Keywords: Worry; Depression

A number of patient-reported outcomes (PROs) predict increased mortality after primary cancer treatment. Studies, though, are sometimes affected by methodological limitations. They often use control variables that poorly life expectancy, examine only one or two PROs thus not controlling potential confounding unmeasured PROs, and observe at a single point in time. To all-cause mortality, this study used affording good estimates conducted multivariate analyses multiple to identify independent predictors, monitored years diagnosis. We recruited consecutive sample 824 patients with uveal melanoma between April 2008 December 2014. were shown previous studies; anxiety, depression, visual ocular symptoms, function impairment, worry about recurrence, physical, emotional, social functional quality (QoL), measured 6, 12 24 months Cox regression census date 2018. Covariates age, gender, marital employment status, self-reported co-morbidities, tumor diameter thickness, treatment modality chromosome 3 mutation the latter genetic strongly associated mortality. Single predictor (with covariates), showed 6-month depression poorer QoL predicting as did 6-12 month increases anxiety decreases physical QoL. Multivariate using all prediction decreasing over 12-24 months. Elevated scores six post-diagnosis constituted an risk. Early intervention for depressive symptoms may reduce