COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report

• DOI: 10.1007/s10875-023-01613-5
• Publication Date: 2024-04-05T05:01:46Z
• Authors: John McDonnell; Kimberley Cousins; M. Elizabeth M. Y...; Adam Lane; Hassan Abolhassani; Roshini S. Abraham; Salem Al-Tamemi; Juan Carlos Aldav...; Eman Hesham Al-Faris; Alberto Alfaro-Mu...; Suzan A. AlKhater; Nouf Alsaati; Alexa Michelle Al...; Melissa Anderson; Ernestina Angarola; Barbara Ariue; Danielle E. Arnold; Amal H. Assa’ad; Caner Aytekin; Meaghan Bank; Jenna R. E. Berge...; Jack Bleesing; John Boesing; Carolina Bouso; Nicholas Brodszki; Diana Cabanillas; Carol Cady; Meghan A. Callahan; Roberta Caorsi; Javier Carbone; Maria Carrabba; Riccardo Castagnoli; Jason R. Catanzaro; Samantha Chan; Sharat Chandra; Hugo Chapdelaine; Zahra Chavoshzadeh; Hey Jin Chong; Lori Connors; Filippo Consonni; Oscar Correa-Jimenez; Charlotte Cunning...; Katherine D’Astou...; Ottavia Maria Del...; Yesim Yilmaz Demi...; Deepti R. Deshpande; Natalie M. Diaz-C...; Victoria R. Dimit...; Rasha El-Owaidy; Gehad ElGhazali; Suleiman Al-Hammadi; Giovanna Fabio; Astrid Schellnast...; Jin Feng; James M. Fernandez; Lauren Fill; Guacira R. Franco; Robert W. Frenck; Ramsay L. Fuleihan; Giuliana Giardino; Jessica Galant-Sw...; Eleonora Gambineri; Elizabeth K. Gara...; Ashley V. Geerlinks; Ekaterini Goudouris; Octavio Grecco; Qiang Pan-Hammars...; Hedieh Haji Khoda...; Lennart Hammarström; Nicholas L. Hartog; Jennifer Heimall; Gabriela Hernande...; Caroline C. Horner; Robert W. Hostoffer; Nataliya Hristova; Kuang-Chih Hsiao; Gabriela Ivankovi...; Faris Jaber; Maaz Jalil; Mahnaz Jamee; Tiffany Jean; Stephanie Jeong; Devi Jhaveri; Michael B. Jordan; Avni Y. Joshi; Amanpreet Kalkat; Henry J. Kanarek; Erinn S. Kellner; Amer Khojah; Ruby Khoury; Cristina M. Kokron; Ashish Kumar; Kelsey Lecerf; Heather K. Lehman; Jennifer W. Leiding; Harry Lesmana; Xin Rong Lim; Joao Pedro Lopes; Ana Laura López; Lucia Tarquini; Ingrid S. Lundgren; Julieann Magnusson; Ana Karolina B. B...; Gian Luigi Marseglia; Giulia M. Martone; Annamaria G. Mech...; Leonardo Mendonca; Joshua D. Milner; Peter J. Mustillo; Asal Gharib Naderi; Samuele Naviglio; Jeremy Nell; Hana B. Niebur; Luigi Notarangelo; Matias Oleastro; María Claudia Ort...; Neil R. Patel; Gordana Petrovic; Claudio Pignata; Oscar Porras; Benjamin T. Prince; Jennifer M. Puck; Nashmia Qamar; Marco Rabusin; Nikita Raje; Lorena Regairaz; Kimberly A. Risma; Elizabeth H. Rist...; John Routes; Persio Roxo-Junior; Negin Salemi; Christopher Scalc...; Susan J. Schuval; Suranjith L. Sene...; Ashwin Shankar; Roya Sherkat; Junghee Jenny Shin; Abeer Siddiqi; Sara Signa; Ali Sobh; Fabiana Mascarenh...; Kristen K. Stenehjem; Jonathan S. Tam; Monica Tang; Myrthes Toledo Ba...; James Verbsky; Eleni Vergadi; Dayne H. Voelker; Stefano Volpi; Luke A. Wall; Christine Wang; Kelli W. Williams; Eveline Y. Wu; Shan Shan Wu; Jessie J. Zhou; Alexandria Cook; Kathleen E. Sullivan; Rebecca Marsh
• Keywords: and promotion of well-being; Epidemiology; Logistic regression; 32 Biomedical and Clinical Sciences; Infectious disease (medical specialty); FOS: Health sciences; Immunization; Immunodeficiency; Outcomes; Viruses: respiratory diseases; Pediatrics; Disease; 3202 Clinical Sciences; Internal medicine; Outcome; Pediatric; Immunology and Microbiology; Vaccines; 0303 health sciences; Vaccination; Life Sciences; 3 Good Health and Well Being; 3204 Immunology; Hospitalization; Infectious Diseases; 3.4 Vaccines; 1107 Immunology; Medicine; Emergency medicine; Original Article; Infection; COVID-19 Vaccines; Critical Care; Immunology; 610; Outcomes; Coronavirus Disease 2019 Research; Vaccine Related; 03 medical and health sciences; Clinical Research; Biodefense; Health Sciences; Epidemiology and Pathogenesis of Respiratory Viral Infections; Immunodeficiency; Humans; 3 Prevention of disease and conditions; Prevention; Genetic Basis of Primary Immunodeficiency Disorders; FOS: Clinical medicine; Immunity; COVID-19; Viruses: respiratory diseases; Coronavirus disease 2019 (COVID-19); Emerging Infectious Diseases; Immunization

Abstract Background The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, whether attenuates infection severity IEI. Objective To estimate examine effect on outcomes Methods We built a secure registry database conjunction the US Immunodeficiency Network to frequency indicators effectiveness IEI patients. opened January 1, 2022, closed August 19, 2022. Results Physicians entered data 1245 from 24 countries. most common diagnoses were antibody deficiencies (63.7%). At least one was administered 806 (64.7%), 216 received prior development COVID-19. vaccines mRNA-based (84.0%). Seventeen reported seek outpatient clinic or emergency room care vaccine-related complication, patient hospitalized symptomatic anemia. Eight hundred twenty-three (66.1%) experienced infection. Of these, 156 required hospitalization (19.0%), 47 ICU (5.7%), 28 died (3.4%). Rates (9.3% versus 24.4%, p < 0.001), admission (2.8% 7.6%, = 0.013), death (2.3% 4.3%, 0.202) who had lower In adjusted logistic regression analysis, not having at significantly increased odds admission. Conclusion Vaccination population appears safe severity.