Syntheses, Crystal Structures and Biological Activity of the 1D Chain Benzyltin Complexes Based on 2-Oxo-Propionic Acid Benzoyl Hydrazone

• DOI: 10.1007/s10904-016-0477-5
• Publication Date: 2016-11-30T12:59:42Z
• Authors: Yu-Xing Tan; Zhi-Jian Zhang; Yong-Lan Feng; Jiang-Xi Yu; Xiao-Ming Zhu; Fu-Xing Zhang; Dai-Zhi Kuang; Wu-Jiu Jiang
• Keywords: Hydrazone; Proton NMR; Cancer cell lines

Two new 1D Chain benzyltin complexes {[C6H4(O)C=N–N=C(Me)COO](CH3OH)(C6H5CH2)2Sn}n (1), {[C6H4(O)C–NH–N=C(Me)COO](C6H5CH2)3Sn}n (2) were synthesized by the reactions of 2-oxo-propionic acid benzoyl hydrazone with dibenzyltin dichloride or tribenzyltin chloride, respectively. The two complexes were characterized by FT-IR, 1H, 13C and 119Sn NMR spectra, elemental analysis, X-ray single crystal diffraction and TGA. In vitro antitumor activities of both complexes were evaluated by the 3-(4,5-dimethylthiazoly-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against three human cancer cell lines (NCI-H460, HepG2, MCF7) and human cell line (HL7702). The 1 exhibited strong antitumor activity than 2, then it was expected after further chemical optimization of candidate compounds as anti-cancer drugs. The interaction between complexes and calf thymus DNA were studied by EB fluorescent probe, the interaction of 1 and 2 with calf thymus DNA were intercalation and electrostatic attraction.