Poly(Ethylene-Co-Vinyl Acetate)–Poly(Lactic Acid)–Poly(Styrene-Co-Methyl Methacrylate) Blends: Study of Mechanical Properties Under Hydrolytic Degradation and Cytotoxic Evaluation

• DOI: 10.1007/s10924-023-03019-1
• Publication Date: 2023-08-31T07:03:01Z
• Authors: Mónica Elvira Men...; Jorge Alberto Roa...; Adriana G. Quiroz...; Elsa N. Garza-Tre...; Celia N. Sánchez-...; Perla Elvia Garcí...; Alejandro Vega-Rios
• Keywords: Biocompatibility; Degradation; Poly(N-isopropylacrylamide)

Abstract The present research investigates the hydrolytic degradation of ternary blends composed poly(ethylene- co -vinylacetate) (EVA), poly(lactic acid) (PLA), and poly(styrene- -methyl methacrylate)(poly(S- -MMA) (SMMA) (EPS) at a temperature 37 °C pH 7.4, monitoring changes in phosphate buffer solution for 6 months. In addition, mechanical behavior morphology were evaluated from comparison with degraded against probes non-hydrolytically degraded. Likewise, hemolytic properties cytotoxicity estimated to determine their safety if used medical devices. Ternary higher stiff-elongated 30 wt% EVA—69 PLA 1 SMMA prepared by varying mixing time each component. EPS samples presented less than PLA. Blending EVA resulted significant stability throughout time. Biocompatibility tests reported that interaction EVA/PLA/SMMA films mesenchymal stem cells showed no evidence damage metabolism cells; thus, not dangerous. Furthermore, all tested values below 5% hemolysis; hence are classified as non slightly according ASTM F756. Therefore, polymer have potential applications Graphical abstract