Assessment of 14C-sulfadiazine on Danio rerio (zebrafish)

• DOI: 10.1007/s10967-018-6058-z
• Publication Date: 2018-08-04T03:43:34Z
• Authors: Aline Trentini Da...; Lucineide Apareci...; Nádia Hortense To...; Luiz Fernando Rom...; Marilia Moura de ...; Ram Naresh Bharagava; Bruno Santos Souza; Mônica Jones Costa; Valdemar Luiz Tor...
• Keywords: Danio; Bioconcentration; Biomagnification

Antimicrobials, besides application in pharmaceuticals, are used as growth promoters in agriculture, especially for cattle, pigs, and poultry production, as well as, complement for fish in aquaculture. In addition to uses mentioned above, the improper disposal of these substances may cause problems in the aquatic environments such as bioaccumulation, bioconcentration and biomagnification. Thus, the aim of this study was to evaluate the bioconcentration and depuration of sulfadiazine using the teleost fish Danio rerio as test organism. During 20 days of exposal to 14C-sulfadiazine, a small amount of the antimicrobial concentration was observed on fish. Further, no depuration was noted during this period.