Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships

• DOI: 10.1007/s10971-016-4097-x
• Publication Date: 2016-06-24T11:44:25Z
• Authors: Anthony L. B. Maçon; Manon Jacquemin; Samuel J. Page; Siwei Li; Sergio Bertazzo; Molly M. Stevens; John V. Hanna; Julian R. Jones
• Keywords: Lithium nitrate

This work reports the synthesis of lithium-silicate glass, containing 10 mol% Li 2 O by sol-gel process, intended for regeneration cartilage. Lithium citrate and lithium nitrate were selected as precursors. The effects precursor on resulting glass structure, morphology, dissolution behaviour, chondrocyte viability proliferation, investigated. When was used, mesoporous a network modifier obtained, whereas use produced relatively dense glass-ceramic with presence metasilicate, shown X-ray diffraction, 29 Si 7 MAS NMR nitrogen sorption data. Nitrate has better affinity than citrate, leading to heterogeneous crystallisation from mesopores, where salts precipitated during drying. Citrate decomposed at lower temperature, crystal is not thermodynamically favourable. Upon decomposition solid-state salt metathesis reaction between silanol occurred, followed diffusion within structure glass. Both released silica ions in culture media, but release rate glass-ceramic. samples did affect proliferation.