Thermoanalytical study of fluoxetine hydrochloride

• DOI: 10.1007/s10973-005-7471-4
• Publication Date: 2007-02-09T18:34:18Z
• Authors: M. A. S. Silva; R. G. Kelmann; T. Foppa; A. P. Cruz; C. D. Bertol; T. Sartori; A. Granada; F. Carmignan; F. S. Murakami
• Keywords: Thermogravimetric analysis

The thermal behaviour of fluoxetine hydrochloride and five capsules available in Florianopolis, Brazil was investigated. The raw material’s purity, kinetic parameters, thermal behaviour and melting characteristics were determined by differential scanning calorimetry and thermogravimetric analysis, as well as the thermal study of the capsules. The purity was 99.12±0.15%. The thermal decomposition followed a zero order kinetic, activation energy of 88.67 kJ mol–1 and frequency factor of 3.539·107 min–1. DSC curves obtained from the capsules suggest compatibility between the drug and excipient.