Association of the Ile50Val Polymorphism of the Interleukin-4 Receptor Gene IL4RA with Chronic Viral Hepatitis

• DOI: 10.1007/s11008-005-0047-3
• Publication Date: 2005-06-28T03:59:56Z
• Authors: I. A. Goncharova; M. B. Friedin; L. E. Dunaeva; E. V. Beloborodova; E. I. Beloborodova; V. P. Puzyrev
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

The Ile50Val polymorphism of the IL4RA gene was tested for association with chronic viral hepatitis and the character of its progression (the stage of hepatic fibrosis). In total, 61 patients were examined. The control group was a random sample of Tomsk residents (N = 128). Genotyping was based on RFLP analysis. The allele and genotype frequencies of the Ile50Val polymorphism did not significantly differ between the patients and the controls. However, a significant difference in genotype frequency distribution was observed for the patients with different stages of hepatic fibrosis. The frequency of heterozygotes Ile/Val in patients without signs of fibrosis was lower than in the control group (7.1% vs. 51.6%, P = 0.002), while the frequency of the homozygous genotypes was higher. In addition, this subgroup significantly differed in genotype frequency distribution from subgroups of patients with early or severe fibrosis (P = 0.035 and P = 0.004, respectively).