The angiotensin-I converting enzyme gene I/D variation contributes to end-stage renal disease risk in Chinese patients with type 2 diabetes receiving hemodialysis

• DOI: 10.1007/s11010-016-2819-6
• Publication Date: 2016-09-16T01:17:40Z
• Authors: Ming Lu; Jianzhong Zhang; Ming Li; Xiaoxu Ge; Xu Dai; Jiao Zhao; Mingzhou Fu; Tao Wang; Xiyao Fang; Can Li; Rong Zhang; Weijing Zhao; Taishan Zheng; Feng Wang; Ming Yu; Tao Lei; Niansong Wang; Yuqian Bao; Limei Liu; Yanjun Liu; Weiping Jia
• Keywords: Male; China; Genotype; Genetic Variation; Middle Aged; Peptidyl-Dipeptidase A; 3. Good health; Diabetes Complications; 03 medical and health sciences; 0302 clinical medicine; Asian People; Diabetes Mellitus, Type 2; Renal Dialysis; Humans; Kidney Failure, Chronic; Female; Aged

Whether the DD genotype of the angiotensin-I converting enzyme (ACE) I/D variation contributes to end-stage renal disease (ESRD) risk in type 2 diabetes mellitus (T2DM) remains controversial. Differences in study design, case and control definition, sample size and ethnicity may contribute to the discrepancies reported in association studies. We performed a case-control study to evaluate the association of the ACE I/D variation with ESRD risk in Chinese patients with T2DM receiving hemodialysis and analyzed the genotype-phenotype interaction. Unrelated Chinese patients (n = 432) were classified into the non-diabetic nephropathy (DN) control group (n = 222, duration of diabetes >10 years, no signs of renal involvement) and the DN-ESRD group (n = 210; ESRD due to T2DM, receiving hemodialysis). Polymerase chain reaction was used to genotype ACE I/D for all 432 subjects. The frequencies of the ID + DD genotypes were higher in the DN-ESRD group than non-DN control group (65.2 vs. 50.9 %; adjusted OR 1.98 (95 % CI, 1.31-3.00; P = 0.001). In the DN-ESRD group, the DD genotypic subgroup had significantly elevated HbA1c and diastolic blood pressure (DBP) compared to the II subgroup (both P < 0.05). The DD genotype of the ACE I/D variation may be associated with more elevated blood pressure and HbA1c, and therefore may predict the development, progression and severity of DN-ESRD in Chinese patients with T2DM undergoing hemodialysis.