The metabolic alterations within the normal appearing brain in patients with Hashimoto’s thyroiditis are correlated with hormonal changes

• DOI: 10.1007/s11011-018-0318-z
• Publication Date: 2018-09-21T22:40:54Z
• Authors: Joanna Bladowska; Marta Waliszewska...; Maria Ejma; Marek Sąsiadek
• Keywords: Adult; Male; 0301 basic medicine; Aspartic Acid; Magnetic Resonance Spectroscopy; Brain; Thyrotropin; Hashimoto Disease; Middle Aged; Neuropsychological Tests; Creatine; White Matter; Choline; 3. Good health; Thyroxine; 03 medical and health sciences; Cognition; Humans; Triiodothyronine; Original Article; Female

Hashimoto's thyroiditis (HT) is the most common autoimmune disease in humans usually associated with subsequent hypothyroidism. The purpose of study was to assess metabolic alterations within normal appearing brain subjects HT using MR spectroscopy (MRS) and correlate MRS measurements hormonal concentrations. Fifty-five patients (mean age 43.5 yrs) 30 healthy controls 42.5 were examined use a 1.5 T scanner. There no signs central nervous system involvement studied group. examinations performed single voxel method. voxels placed left parietal white matter (PWM) posterior cingulate gyrus (PCG). NAA/Cr, Cho/Cr, mI/Cr ratios calculated. correlations between metabolite concentrations (TSH, fT3, fT4) as well anti-TG anti-TPO levels also assessed. We found significantly (p < 0.05) decreased NAA/Cr PCG PWM compared control other significant differences ratios. observed positive ratio fT3 level. negative correlation Cho/Cr fT4 could be sensitive biomarker capable depicting early cerebral disturbances HT. Our findings may indicate reduction neuronal activity suggesting that there possible biological association thyroid dysfunction changes.