Diammonium hydrogen phosphate as a versatile and efficient catalyst for the one-pot synthesis of pyrano[2,3-d]pyrimidinone derivatives in aqueous media

• DOI: 10.1007/s11030-008-9079-7
• Publication Date: 2008-05-29T08:17:46Z
• Authors: Saeed Balalaie; Shahrzad Abdolmoh...; Hamid Reza Bijanz...; Ali Mohammad Amani
• Keywords: Barbituric acid; Diammonium phosphate; Hydrogen phosphate; Aqueous medium; Condensation reaction

Diammonium hydrogen phosphate, (NH4)2HPO4, was used as a catalyst for one-pot, three-component condensation reactions consisting of aromatic aldehydes, malononitrile and barbituric/thiobarbituric acid in aqueous ethanol at room temperature. This method has the advantages of a simple operation, mild reaction conditions, high yields, by using a less toxic and low cost chemical as a catalyst.