The −930A>G polymorphism of the CYBA gene is associated with premature coronary artery disease. A case–control study and gene–risk factors interactions

• DOI: 10.1007/s11033-014-3191-9
• Publication Date: 2014-01-30T01:55:38Z
• Authors: Pawel Niemiec; Tomasz Nowak; Tomasz Iwanicki; Jolanta Krauze; Sylwia Gorczynska...; Wladyslaw Grzeszczak; Anna Ochalska-Tyka; Iwona Zak
• Keywords: SNP

Reactive oxygen species (ROS) are involved in the pathogenesis of atherosclerosis and coronary artery disease (CAD). NADPH oxidases main source ROS vasculature. p22phox is a critical component vascular encoded by CYBA (cytochrome b245 alpha) gene. The −930A>G polymorphism (rs9932581:A>G) modulates activity promoter, influences transcriptional activity. aim present study was to analyze possible association between CAD search for gene–traditional risk factors interactions. 480 subjects were studied: 240 patients with premature CAD, age sex matched blood donors. genotyped using TaqMan® Pre-designed SNP Genotyping Assay (Applied Biosystems). −930G allele carrier state factor (OR 2.03, 95 % CI 1.21–3.44, P = 0.007). A synergistic effect overweight/obesity (BMI ≥ 25) cigarette smoking found. estimated BMI 25 interaction about 160 greater than that predicted assuming additivity effects, 40 allele. Overweight/obesity only carriers (P < 10−10) but not AA homozygotes 1.00). In conclusion associated Polish population. particularly at consequences obesity tobacco smoke exposure.