Porous silicon nanoparticles as scavengers of hazardous viruses

• DOI: 10.1007/s11051-014-2430-2
• Publication Date: 2014-05-09T04:28:42Z
• Authors: L. A. Osminkina; V. Yu Timoshenko; I. P. Shilovsky; G. V. Kornilaeva; S. N. Shevchenko; M. B. Gongalsky; K. P. Tamarov; S. S. Abramchuk; V. N. Nikiforov; M. R. Khaitov; E. V. Karamov
• Keywords: 02 engineering and technology; 0210 nano-technology; 3. Good health

We report that silicon nanoparticles (SiN- Ps) with typical sizes from 5 to 50 nm prepared by grinding of porous silicon can act as efficient scavengers of human immunodeficiency virus (HIV) and respiratory syncytial virus (RSV). In vitro studies have revealed a strong suppression of the viral activity in the presence of SiNPs with concentration above 0.1 and 0.01 mg/mL for HIV and RSV, respectively. The observed effect is explained by binding of the virions with SiNPs that is supposed to be universal for different enveloped viruses. Because of the cytotoxic concentration of SiNPs is of the order of 1 mg/mL, SiNPs can be proposed for applications in new harmless methods of antiviral treatment.