Characteristics of extinction of a conditioned passive avoidance reflex in mice with different levels of anxiety

• DOI: 10.1007/s11055-007-0145-x
• Publication Date: 2006-12-15T19:37:23Z
• Authors: N. I. Dubrovina; R. A. Tomilenko
• Keywords: Extinction (optical mineralogy); Engram; Conditioned reflex; Avoidance learning; Elevated plus maze

The relationship between the extinction of a conditioned passive avoidance reflex and the initial anxiety level was studied in mice. The time spent in the open arms of an elevated cross maze was used to classify the mice into high-, intermediate-and low-anxiety individuals. Each level of anxiety was found to correspond to a defined extinction dynamic. Highly anxious mice were characterized by the absence of extinction of the conditioned passive avoidance reflex and stability of good reproduction of the memory trace on testing to as long as 15 days. In intermediately anxious individuals, a deficit in performance of the avoidance reflex appeared from day 7 of extinction. In low-anxiety mice, memory trace reproduction deteriorated from test day 11.