Surgical treatment and survival outcome of patients with adult thalamic glioma: a single institution experience of 8 years

• DOI: 10.1007/s11060-020-03430-x
• Publication Date: 2020-03-10T12:02:52Z
• Authors: Xiaodong Niu; Tianwei Wang; Xingwang Zhou; Yuan Yang; Xiang Wang; Haodongfang Zhang; Ni Chen; Qiang Yue; Feng Wang; Yuekang Zhang; Yanhui Liu; Qing Mao
• Keywords: Adult; Male; Adolescent; Brain Neoplasms; Glioma; Middle Aged; Prognosis; Neurosurgical Procedures; 3. Good health; Survival Rate; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Thalamic Nuclei; Humans; Female; Aged; Follow-Up Studies; Retrospective Studies

Given the rarity in the population with adult thalamic gliomas (ATGs), comprehensive characteristics, treatments and survival outcome are not well characterized. This study was conducted to investigate the comprehensive characteristic and treatment of ATGs and identify the prognostic factors associated with overall survival (OS).A retrospective analysis of newly diagnosed ATGs who underwent surgical resection consecutively was conducted. Survival analysis of OS was performed by Kaplan-Meier analysis. Cox proportional hazard model was used to investigate the possible prognostic factors associated with OS.A total of 102 patients with ATG were enrolled in this study. The median age was 41 years (range 18-68 years). There were 56 (54.9%) males. Sixty-two patients (60.8%) had glioblastoma (GBM). Among these patients, 46 patients (45.1%) had GTR/NTR, 50 patients (49.0%) had STR and 6 patients (5.9%) had PR. Postoperatively, 71.6% of these patients received adjuvant therapy. The median OS was 13.6 months (range 1 week-75 months). COX regression analysis revealed that ATG patients with longer duration of symptoms (p = 0.024), better pre-KPS (p = 0.045), maximal resection (p = 0.013), or lower tumor grade (p = 0.002) had longer OS, and these predictors are considered as independent prognostic factors. Survival analysis showed that ATGs with GTR/NTR plus chemoradiotherapy had significant OS advantage compared with other treatment regimens.This study comprehensively summarized the characteristics, treatments and survival outcomes of ATGs in the largest sample size. Maximal surgical resection can bring survival benefit. Combined-modality therapy regimen of GTR/NTR plus chemoradiotherapy may be better beneficial for OS than other regimens.