The importance of considering competing risks in recurrence analysis of intracranial meningioma

• DOI: 10.1007/s11060-024-04572-y
• Publication Date: 2024-02-10T04:20:50Z
• Authors: Christian Mirian; Lasse Rehné Jensen; Tareq A. Juratli; Andrea Daniela Maier; Sverre H. Torp; Helen A. Shih; Ramin A. Morshed; Jacob S. Young; Stephen T. Magill; Luca Bertero; Walter Stummer; Dorothee Cäcilia ...; Benjamin Brokinkel; Soichi Oya; Satoru Miyawaki; Nobuhito Saito; Martin Proescholdt; Yasuhiro Kuroi; Konstantinos Gousias; Matthias Simon; Jennifer Moliterno; Ricardo Prat-Acin; Stéphane Goutagny; Vikram C. Prabhu; John T. Tsiang; Johannes Wach; Erdem Güresir; Junkoh Yamamoto; Young Zoon Kim; Joo Ho Lee; Matthew Koshy; Karthikeyan Perumal; Mustafa K. Baskaya; Donald M. Cannon; Dennis C. Shrieve; Chang-Ok Suh; Jong Hee Chang; Maria Kamenova; Sven Straumann; Jehuda Soleman; Ilker Y. Eyüpoglu; Tony Catalan; Austin Lui; Philip V. Theodos...; Michael W. McDermott; Fang Wang; Fuyou Guo; Pedro Góes; Manoel Antonio de...; Aria Jamshidi; Ricardo Komotar; Michael Ivan; Evan Luther; Luis Souhami; Marie-Christine G...; Tamás Csonka; Toshiki Endo; Olivia Claire Bar...; Randy Jensen; Tejpal Gupta; Akash J. Patel; Tiemo J. Klisch; Jun Won Kim; Francesco Maiuri; Valeria Barresi; María Dolores Tab...; Simon Skyrman; Anders Broechner; Mathias Jacobsen ...; Ian Law; David Scheie; Bjarne Winther Kr...; Tina Nørgaard Munch; Torstein Meling; Kåre Fugleholm; Paul Blanche; Tiit Mathiesen
• Keywords: Medical Sciences; Mental and Social Health; Research; Neurosciences; 610; Competing risk; Risk Assessment; Neoplasm Recurrence; Neurology; Local; Recurrence; Neuro-oncology; Medical Specialties; Medicine and Health Sciences; Meningeal Neoplasms; Humans; Neoplasm Recurrence, Local; Meningioma; Competing risk; Meningioma; Neuro-oncology; Recurrence; Aged; Retrospective Studies

Abstract Background The risk of recurrence is overestimated by the Kaplan–Meier method when competing events, such as death without recurrence, are present. Such overestimation can be avoided using Aalen-Johansen method, which a direct extension that accounts for events. Meningiomas commonly occur in older individuals and have slow-growing properties, thereby warranting analysis. extent to events considered meningioma literature unknown, consequences incorrect methodologies analysis not been investigated. Methods We surveyed articles indexed on PubMed since 2020 assess usage recent literature. To compare estimates obtained through methods, we applied our international database comprising ~ 8,000 patients with primary collected from 42 institutions. Results Of 513 articles, 169 were eligible full-text screening. There 6,537 cases PERNS database. discrepancy between results was negligible among low-grade lesions younger individuals. increased substantially patient groups associated higher rates (older high-grade lesions). Conclusion importance considering poorly recognized only 6% studies employed analyses. Consequently, most previous has recurrence. involving individuals; however, might substantial lesions.