Blood-tumor barrier in focus - investigation of glioblastoma-induced effects on the blood-brain barrier

• DOI: 10.1007/s11060-024-04760-w
• Publication Date: 2024-08-28T07:02:29Z
• Authors: Sanjana Mathew-Sc...; Matthias Peindl; Philipp Neundorf; Gudrun Dandekar; Marco Metzger; Vera Nickl; Antje Appelt-Menzel
• Keywords: Occludin; Spheroid; U87

Glioblastoma (GBM) is the most prevalent, malignant, primary brain tumor in adults, characterized by limited treatment options, frequent relapse, and short survival after diagnosis. Until now, none of existing therapy approaches have proven to be an effective cure. The availability predictive human blood-tumor barrier (BTB) test systems that can mimic in-vivo pathophysiology GBM would great interest preclinical research. Here, we present establishment a new BTB in-vitro system combining spheroids BBB models derived from induced pluripotent stem cells (hiPSCs).