A genetically encoded indicator for monitoring intracellular chloride

• DOI: 10.1007/s11062-007-0047-0
• Publication Date: 2008-02-02T07:12:20Z
• Authors: O. Markova; E. Réal; Y. Jacob; M. Mukhtarov; P. Bregestovski
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

Inhibitory drives in the nervous system are provided by synapses operating mostly through Cl− ion channels. We describe a novel CFP-YFP-based fluorescence Cl− indicator, Cl-sensor, characterized by a high sensitivity, which can be successfully used as a tool for monitoring intracellular Cl− in various biological preparations.