Evaluation of the Anticonvulsant Effect of Brilliant Blue G, a Selective P2X7 Receptor Antagonist, in the iv PTZ-, Maximal Electroshock-, and 6 Hz-Induced Seizure Tests in Mice

• DOI: 10.1007/s11064-017-2348-z
• Publication Date: 2017-07-12T01:37:16Z
• Authors: Dorota Nieoczym; Katarzyna Socała; Piotr Wlaź
• Keywords: Seizure threshold; Motor coordination

Epilepsy is one of the most common neurological disorders which diagnosed in around 65 million people worldwide. Clinically available antiepileptic drugs fail to control epileptic activity about 30% patients and they are merely symptomatic treatments cannot cure or prevent epilepsy. There remains a need for searching new therapeutic strategies disorders. The P2X7 receptor has been recently investigated as target epilepsy treatment. Preclinical studies revealed that antagonists have anticonvulsant properties some models We aimed investigate whether antagonist—brilliant blue G (BBG)—is able change seizure threshold three acute mice, i.e., intravenous pentylenetetrazole threshold, maximal electroshock 6 Hz psychomotor tests. BBG was administered acutely (50–200 mg/kg, 30 min before tests) sub-chronically (25–100 once daily seven consecutive days). Moreover, chimney grip strength tests were used estimate influence on motor coordination muscular respectively. Our results only week potential studied antagonist because it showed action test, both after sub-chronic administration. did not significantly thresholds remaining Motor affected by antagonist. In summary, does possess any remarkable mice.