Synthesis, toxicity, and percutaneous activity of silicon glycerolates and related hydrogels

• DOI: 10.1007/s11094-009-0199-x
• Publication Date: 2009-03-25T11:01:58Z
• Authors: T. G. Khonina; O. N. Chupakhin; L. P. Larionov; T. G. Boyakovskaya; A. L. Suvorov; E. V. Shadrina
• Keywords: 01 natural sciences; 3. Good health; 0104 chemical sciences

Silicon glycerolates of the general formula Si(C3H7O3)4 ⋅ xC3H8O3(3 ≤ x ≤ 10) and related hydrogels of the general formula Si(C3H7O3)4 ⋅ xC3H8O3 ≤ yH2O (3 ≤ x ≤ 10, 20 ≤ y ≤ 40) were synthesized and some of their pharmacological properties were studied. The laws of gel formation were investigated and optimum conditions for the process were determined. High percutaneous (transdermal) activity of the synthesized compounds was revealed by measuring the diffusion of drugs through intact skin membrane in vitro. The acute and chronic toxicity was studied. It was established that all substances are nontoxic. The experimental results show that silicon glycerolates and related hydrogels can be recommended for further testing and investigation as effective biologically active percutaneous vehicles of medicinal preparations.