Increasing the solubility of an angioprotector by the method of solid dispersions

• DOI: 10.1007/s11094-009-0326-8
• Publication Date: 2009-11-19T05:17:03Z
• Authors: R. U. Khabriev; V. A. Popkov; V. Yu. Reshetnyak; I. I. Krasnyuk; O. V. Manakhova
• Keywords: Polyvinylpyrrolidone

The effect of solid dispersions (SDs) on the solubility of parmidin has been studied by comparing the solubility of parmidin, its SDs, and physical mixtures with polyethyleneglycol-1500, polyvinylpyrrolidone-10000, and β-cyclodextrin. It is established that the formulation of SDs increases the solubility and the dissolution rate of parmidin. Data obtained using a complex of physical and chemical methods suggest that improvement of the drug release from SDs is due to the solubilization and the formation of a colloidal-dispersion state of the given substance.