Solubility of erythromycin from solid dispersions
Polyvinylpyrrolidone
Complex formation
DOI:
10.1007/s11094-010-0367-z
Publication Date:
2010-02-17T08:40:41Z
AUTHORS (5)
ABSTRACT
The effect of solid dispersion (SD) formation on the solubility of the antibiotic erythromycin has been studied using the parent substance of erythromycin and its SDs with polyethyleneglycol (PEG-1500), polyvinylpyrrolidone (PVP-10000), and β-cyclodextrin. It is established that SD formation increases the solubility of the antibiotic by a factor of 1.3 – 1.8; the dissolution rate, 1.5 – 2.0. Results using a complex of physical and chemical methods suggest that the increase in erythromycin release from SDs takes place due to a decrease in the degree of crystallinity and the formation of intermolecular complexes.
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