Increasing the solubility of phenazepam by forming solid dispersions

• DOI: 10.1007/s11094-010-0448-z
• Publication Date: 2010-10-14T07:06:02Z
• Authors: I. I. Krasnyuk; O. V. Manakhova; R. U. Khabriev; V. A. Popkov; V. Yu. Reshetnyak; O. I. Krasnyuk
• Keywords: 02 engineering and technology; 0204 chemical engineering

The effect of solid dispersion (SD) formation on the solubility of phenazepam has been studied. Phenazepam and its SDs with poly(ethyleneglycol)-1500 (PEG), poly(vinylpyrrolidone)-10000 (PVP), and β-cyclodextrin were studied. The SD with PVP increases both the solubility and the dissolution rate of phenazepam. Results obtained by a complex of physical and chemical methods suggest that the improved release of phenazepam from the SD with PVP is due to solubilization, amorphization, and formation of a colloidal dispersion of the parent drug substance.