Assay and therapeutic monitoring of fluvoxamine

• DOI: 10.1007/s11094-011-0533-y
• Publication Date: 2011-03-18T01:48:47Z
• Authors: O. Yu. Kravtsova; I. I. Miroshnichenko
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 01 natural sciences; 0104 chemical sciences; 3. Good health

A highly sensitive and reproducible method for assay of fluvoxamine in biological samples using HPLC combined with various detection methods (spectrophotometry and tandem mass spectrometry) was developed. These methods were completely interchangeable and correlation analysis demonstrated high consistency in the results obtained by different detection methods: the Pearson correlation coefficient was 0.982 (p < 0.0001) and the slope of the regression line was close to unity. The methods were suitable for routine therapeutic monitoring of fluvoxamine in patients’ serum.