Synthesis and Antibacterial Activity of Bis-[1-(Adamantan-1-Yl)Ethyl]Amine Hydrochloride

• DOI: 10.1007/s11094-016-1379-0
• Publication Date: 2016-04-02T00:18:23Z
• Authors: V. I. Krylov; S. V. Moiseev; A. A. Kutin; N. G. Sakhno; O. V. Gunar; V. A. Yashkir; V. A. Merkulov
• Keywords: Rimantadine; Hydrochloride

An impurity in rimantadine hydrochloride drug substance that was previously undescribed in regulatory documents and the literature was identified. Its structure was elucidated and confirmed by a convergent synthesis. A method for synthesizing bis-[1-(adamantan-1-yl)ethyl]amine hydrochloride under laboratory conditions was developed. The antibacterial activity of the synthesized compound was assessed.