Synthesis and Antidiabetic Activity of Thiazolo[2,3-f]Purine Derivatives and Their Analogs

• DOI: 10.1007/s11094-017-1649-5
• Publication Date: 2017-11-02T05:39:20Z
• Authors: A. A. Spasov; F. A. Khaliullin; D. A. Babkov; G. A. Timirkhanova; V. A. Kuznetsova; L. V. Naumenko; D. R. Muleeva; O. Yu. Maika; T. Yu. Prokhorova; E. A. Sturova
• Keywords: 0301 basic medicine; 0303 health sciences; 03 medical and health sciences

Thiazolo[2, 3-f]purine derivatives and their analogs – dihydrothiazolo[2, 3-f]purine, 7-(thietan-3-yl)purine, and 8-(2-hydroxypropylthio)purine derivatives – were synthesized. The compounds synthesized here had no effects on protein glycation reactions using glucose; they gave weak inhibition of glycogen phosphorylase; they had no hemorheological activity. Substances with hypotensive activity greater than that of Dibazol were found. A number of substances had hypoglycemic effects greater than those of chlorpropamide and Adebit. Two compounds inhibited dipeptidylpeptidase-4, but were less active than reference agent vildagliptin.