Synthesis and Antimicrobial Activity of 4-Hydroxy-2-[5-Nitrofuran(Thien)-2-Yl]-6h-1,3-Oxazin-6-Ones

• DOI: 10.1007/s11094-017-1668-2
• Publication Date: 2017-11-10T10:11:52Z
• Authors: N. M. Chernov; A. S. Koshevenko; I. P. Yakovlev; E. P. Anan’eva; G. V. Ksenofontova; A. E. Shchegolev
• Keywords: 01 natural sciences; 0104 chemical sciences; 3. Good health

A series of new 4-hydroxy-6H-oxazin-6-ones containing 2-(5-nitrofuranyl) and 2-(5-nitrothienyl) moieties were obtained. New nitrofuran and thiophene derivatives were synthesized by reacting these oxazines with mono- (EtOH) and dinucleophiles (phenylhydrazine). It was established that the synthesized compounds possessed pronounced bactericidal activity against Staphylococcus aureus and, in some cases, Escherichia coli strains.