Synthesis and Antidepressant Properties of 3-Methyl-7-(1,1-Dioxothietan-3-YL)-8-Cyclohexylamino-1-Ethyl-1H-Purine-2,6(3H,7H)-Dione

• DOI: 10.1007/s11094-018-1738-0
• Publication Date: 2018-03-12T04:33:47Z
• Authors: F. A. Khaliullin; Yu. V. Shabalina; G. G. Davlyatova; L. A. Valeeva
• Keywords: 01 natural sciences; 3. Good health; 0104 chemical sciences

3-Methyl-7-(1,1-dioxothietan-3-yl)-8-cyclohexylamino-1-ethyl-1H-purine-2,6(3H,7H)-dione was synthesized via the reaction of 8-bromo-3-methyl-7-(1,1-dioxothietan-3-yl)-1-ethyl-1H-purine-2,6(3H,7H)-dione and cyclohexylamine and exhibited antidepressant activity that was most pronounced at a dose of 1.6 mg/kg.